How Long Does It Take to Lose 25 Pounds on a GLP-1?
Short answer: using average results from published clinical trials, losing 25 pounds takes 5 to 24+ months on semaglutide and 3 to 9 months on tirzepatide, depending on your starting weight. Someone starting at 200 pounds and aiming for 175 would need to lose 12.5% of their body weight, which our model projects at 14 months on semaglutide and 6 months on tirzepatide.
Estimated time to lose 25 pounds by starting weight
| Start | Goal | % of body weight | Semaglutide | Tirzepatide |
|---|---|---|---|---|
| 160 lbs | 135 lbs | 15.6% | 24+ months | 9 months |
| 180 lbs | 155 lbs | 13.9% | 20 months | 8 months |
| 200 lbs | 175 lbs | 12.5% | 14 months | 6 months |
| 220 lbs | 195 lbs | 11.4% | 11 months | 6 months |
| 250 lbs | 225 lbs | 10% | 9 months | 5 months |
| 300 lbs | 275 lbs | 8.3% | 6 months | 4 months |
| 350 lbs | 325 lbs | 7.1% | 5 months | 3 months |
"24+ months" means the goal is not reached within the 24-month window our model covers. Estimates use the average outcomes from the STEP 1 (semaglutide) and SURMOUNT-1 (tirzepatide) trials and are not a prediction for any individual.
Why the same 25 pounds takes different amounts of time
Trial results are reported as a percentage of starting body weight, not a fixed number of pounds. Losing 25 pounds is a smaller share of body weight for someone who starts heavier, so it can be reached sooner, while the same 25 pounds is a much bigger share for someone lighter. Loss is also fastest early on and slows as it approaches a plateau, so the last few pounds take disproportionately longer.
Get your own estimate
The table uses round starting weights. Enter your exact current weight and goal weight in the calculator to see a month-by-month timeline for both medications.
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Try the Free GLP-1 CalculatorMedical Disclaimer
This calculator is for educational and informational purposes only and does not provide medical advice, diagnose any condition, recommend or prescribe treatment, or guarantee results. Estimates are based on information you provide and published clinical-trial averages. Individual results can vary significantly.
Estimates are based on average outcomes reported in the STEP 1 (semaglutide) and SURMOUNT-1 (tirzepatide) clinical trials. Individual results can vary significantly and are influenced by factors such as dosage, diet, and adherence.
Do not start, stop, or change any medication based on the results of this calculator. Always consult a qualified healthcare professional regarding medications, treatment options, risks, side effects, and your individual health needs.